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Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung
| Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Chichester, : Wiley, 2008 |
| Descrizione fisica | 1 online resource (332 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) | ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory muscles - Physiology
Smooth muscle - Physiology Respiratory muscles - Molecular aspects Smooth muscle - Molecular aspects Respiratory agents Respiratory organs - Diseases - Treatment Respiratory therapy |
| ISBN |
1-282-34322-X
9786612343223 0-470-75422-2 0-470-75421-4 |
| Formato | Materiale a stampa  |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Airway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 1.1 Introduction; 1.2 Airway hyperresponsiveness; 1.3 Classical behaviour of airway smooth muscle and the balance of static forces; 1.4 Shortening velocity and other manifestations of muscle dynamics; 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture?; 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle; 1.7 Recent observations; 1.8 Future directions; References
2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction2.1 Introduction; 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell; 2.3 Cytoskeletal dynamics and airway smooth muscle contraction; References; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 3.1 What is airway constrictor hyperresponsiveness (AHR)?; 3.2 Is AHR ever good?; 3.3 Potential mechanisms leading to airflow obstruction 3.4 Potential abnormalities of airway smooth muscle (ASM)3.5 If ASM is dysfunctional, how did it get that way?; 3.6 Summary; Acknowledgements; References; 4 Airway smooth muscle phenotypic and functional plasticity; 4.1 Introduction; 4.2 Historical perspective: smooth muscle phenotype plasticity; 4.3 Features of phenotype plasticity; 4.4 Mechanisms for phenotypic plasticity; 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis; 4.6 Concluding remarks; References; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation; References; 6 Airway smooth muscle bidirectional interactions with extracellular matrix; 6.1 Overview; 6.2 Introduction; 6.3 Airway extracellular matrix (ECM) in health and disease; 6.4 Integrins; 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM; 6.6 Airway ECM as modulator of ASM function; 6.7 Impact of anti-asthma therapy on ASM-ECM interactions; 6.8 Conclusions; Acknowledgements; References 7 Airway smooth muscle interaction with mast cells7.1 Introduction; 7.2 Mast cell mediators alter smooth muscle function; 7.3 Smooth muscle cells induce mast cell chemotaxis; 7.4 Mast cells can adhere to airway smooth muscle; 7.5 Conclusion; Acknowledgements; References; 8 Airway smooth muscle synthesis of inflammatory mediators; 8.1 Introduction; 8.2 Lipid mediators; 8.3 Chemokines; 8.4 Growth and remodelling factors; 8.5 Conclusions; References; 9 Airway smooth muscle in experimental models; 9.1 Introduction; 9.2 Methods of assessment of airway smooth muscle (ASM) function 9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness |
| Record Nr. | UNINA-9910144704303321 |
| Hoboken, N.J. ; ; Chichester, : Wiley, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung
| Airway smooth muscle in asthma and COPD [[electronic resource] ] : biology and pharmacology / / edited by Kian Fan Chung |
| Pubbl/distr/stampa | Hoboken, N.J. ; ; Chichester, : Wiley, 2008 |
| Descrizione fisica | 1 online resource (332 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) | ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory muscles - Physiology
Smooth muscle - Physiology Respiratory muscles - Molecular aspects Smooth muscle - Molecular aspects Respiratory agents Respiratory organs - Diseases - Treatment Respiratory therapy |
| ISBN |
1-282-34322-X
9786612343223 0-470-75422-2 0-470-75421-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Airway Smooth Muscle; Contents; List of Contributors; 1 Biophysical basis of airway smooth muscle contraction and hyperresponsiveness in asthma; 1.1 Introduction; 1.2 Airway hyperresponsiveness; 1.3 Classical behaviour of airway smooth muscle and the balance of static forces; 1.4 Shortening velocity and other manifestations of muscle dynamics; 1.5 Biophysical characterization of airway smooth muscle: bronchospasm in culture?; 1.6 Mechanical plasticity: a nonclassical feature of airway smooth muscle; 1.7 Recent observations; 1.8 Future directions; References
2 Dynamics of cytoskeletal and contractile protein organization: an emerging paradigm for airway smooth muscle contraction2.1 Introduction; 2.2 Molecular structure and organization of contractile and cytoskeletal filaments in the airway smooth muscle cell; 2.3 Cytoskeletal dynamics and airway smooth muscle contraction; References; 3 Airway smooth muscle: role in airway constrictor hyperresponsiveness; 3.1 What is airway constrictor hyperresponsiveness (AHR)?; 3.2 Is AHR ever good?; 3.3 Potential mechanisms leading to airflow obstruction 3.4 Potential abnormalities of airway smooth muscle (ASM)3.5 If ASM is dysfunctional, how did it get that way?; 3.6 Summary; Acknowledgements; References; 4 Airway smooth muscle phenotypic and functional plasticity; 4.1 Introduction; 4.2 Historical perspective: smooth muscle phenotype plasticity; 4.3 Features of phenotype plasticity; 4.4 Mechanisms for phenotypic plasticity; 4.5 Functional plasticity of airway smooth muscle: role in asthma pathogenesis; 4.6 Concluding remarks; References; 5 Airway smooth muscle proliferation: insights into mechanisms regulating airway smooth muscle mass 5.1 Increases in airway smooth muscle (ASM) mass and the functional consequences5.2 Growth factors, inflammatory mediators and cytokines modulate ASM proliferation; References; 6 Airway smooth muscle bidirectional interactions with extracellular matrix; 6.1 Overview; 6.2 Introduction; 6.3 Airway extracellular matrix (ECM) in health and disease; 6.4 Integrins; 6.5 Airway smooth muscle (ASM) as a modulator of airway ECM; 6.6 Airway ECM as modulator of ASM function; 6.7 Impact of anti-asthma therapy on ASM-ECM interactions; 6.8 Conclusions; Acknowledgements; References 7 Airway smooth muscle interaction with mast cells7.1 Introduction; 7.2 Mast cell mediators alter smooth muscle function; 7.3 Smooth muscle cells induce mast cell chemotaxis; 7.4 Mast cells can adhere to airway smooth muscle; 7.5 Conclusion; Acknowledgements; References; 8 Airway smooth muscle synthesis of inflammatory mediators; 8.1 Introduction; 8.2 Lipid mediators; 8.3 Chemokines; 8.4 Growth and remodelling factors; 8.5 Conclusions; References; 9 Airway smooth muscle in experimental models; 9.1 Introduction; 9.2 Methods of assessment of airway smooth muscle (ASM) function 9.3 Potential mechanisms by which ASM properties may contribute to airway responsiveness |
| Record Nr. | UNINA-9910829163303321 |
| Hoboken, N.J. ; ; Chichester, : Wiley, 2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cough [[electronic resource] ] : causes, mechanisms, and therapy / / edited by Kian Fan Chung, John G. Widdicombe, Homer A. Boushey
| Cough [[electronic resource] ] : causes, mechanisms, and therapy / / edited by Kian Fan Chung, John G. Widdicombe, Homer A. Boushey |
| Pubbl/distr/stampa | Malden, Mass., : Blackwell Pub., 2003 |
| Descrizione fisica | 1 online resource (318 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) |
ChungK. Fan <1951->
WiddicombeJohn G BousheyHomer A |
| Soggetto topico | Cough |
| ISBN |
1-281-21466-3
9786611214661 0-470-75503-2 0-470-75584-9 1-4051-2853-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cough: Causes, Mechanisms and Therapy; Contents; Contributors; Preface; Section 1: Introduction; 1 The clinical and pathophysiological challenge of cough; 2 Epidemiology of cough; 3 A brief overview of the mechanisms of cough; Section 2: Cough in the Clinic; 4 Clinical assessment of cough; 5 Measurement and assessment of cough; 6 Cough sensitivity: the use of provocation tests; 7 Causes, assessment and measurement of cough in children; 8 The quality of life in coughers; Section 3: Clinical Conditions with Cough; 9 Cough in lower airway infections; 10 Cough and gastro-oesophageal reflux
11 Cough in postnasal drip, rhinitis and rhinosinusitis12 Cough and airway hyperresponsiveness; 13 Cough in chronic obstructive pulmonary disease; 14 Cough in suppurative airway diseases; 15 Cough in cancer patients; Section 4: Pathophysiology; 16 Sensory pathways for the cough reflex; 17 Neurogenesis of cough; 18 Plasticity of vagal afferent fibres mediating cough; 19 Motor mechanisms and the mechanics of cough; 20 Mucus hypersecretion and mucus clearance in cough; 21 Animal models of cough; Section 5: Therapy 22 Mechanisms of actions of centrally acting antitussives-electrophysiological and neurochemical analysis23 Pharmacology of peripherally acting antitussives; 24 Current and potential future antitussive therapies; 25 Placebo effects of antitussive treatments on cough associated with acute upper respiratory tract infection; 26 Mucoactive agents for the treatment of cough; 27 Management of cough; Index |
| Record Nr. | UNINA-9910143292603321 |
| Malden, Mass., : Blackwell Pub., 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cough [[electronic resource] ] : causes, mechanisms, and therapy / / edited by Kian Fan Chung, John G. Widdicombe, Homer A. Boushey
| Cough [[electronic resource] ] : causes, mechanisms, and therapy / / edited by Kian Fan Chung, John G. Widdicombe, Homer A. Boushey |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Malden, Mass., : Blackwell Pub., 2003 |
| Descrizione fisica | 1 online resource (318 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) |
ChungK. Fan <1951->
WiddicombeJohn G BousheyHomer A |
| Soggetto topico | Cough |
| ISBN |
1-281-21466-3
9786611214661 0-470-75503-2 0-470-75584-9 1-4051-2853-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cough: Causes, Mechanisms and Therapy; Contents; Contributors; Preface; Section 1: Introduction; 1 The clinical and pathophysiological challenge of cough; 2 Epidemiology of cough; 3 A brief overview of the mechanisms of cough; Section 2: Cough in the Clinic; 4 Clinical assessment of cough; 5 Measurement and assessment of cough; 6 Cough sensitivity: the use of provocation tests; 7 Causes, assessment and measurement of cough in children; 8 The quality of life in coughers; Section 3: Clinical Conditions with Cough; 9 Cough in lower airway infections; 10 Cough and gastro-oesophageal reflux
11 Cough in postnasal drip, rhinitis and rhinosinusitis12 Cough and airway hyperresponsiveness; 13 Cough in chronic obstructive pulmonary disease; 14 Cough in suppurative airway diseases; 15 Cough in cancer patients; Section 4: Pathophysiology; 16 Sensory pathways for the cough reflex; 17 Neurogenesis of cough; 18 Plasticity of vagal afferent fibres mediating cough; 19 Motor mechanisms and the mechanics of cough; 20 Mucus hypersecretion and mucus clearance in cough; 21 Animal models of cough; Section 5: Therapy 22 Mechanisms of actions of centrally acting antitussives-electrophysiological and neurochemical analysis23 Pharmacology of peripherally acting antitussives; 24 Current and potential future antitussive therapies; 25 Placebo effects of antitussive treatments on cough associated with acute upper respiratory tract infection; 26 Mucoactive agents for the treatment of cough; 27 Management of cough; Index |
| Record Nr. | UNINA-9910823933503321 |
| Malden, Mass., : Blackwell Pub., 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Cough [[electronic resource] ] : causes, mechanisms, and therapy / / edited by Kian Fan Chung, John G. Widdicombe, Homer A. Boushey
| Cough [[electronic resource] ] : causes, mechanisms, and therapy / / edited by Kian Fan Chung, John G. Widdicombe, Homer A. Boushey |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Malden, Mass., : Blackwell Pub., 2003 |
| Descrizione fisica | 1 online resource (318 p.) |
| Disciplina | 616.2 |
| Altri autori (Persone) |
ChungK. Fan <1951->
WiddicombeJohn G BousheyHomer A |
| Soggetto topico | Cough |
| ISBN |
1-281-21466-3
9786611214661 0-470-75503-2 0-470-75584-9 1-4051-2853-4 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Cough: Causes, Mechanisms and Therapy; Contents; Contributors; Preface; Section 1: Introduction; 1 The clinical and pathophysiological challenge of cough; 2 Epidemiology of cough; 3 A brief overview of the mechanisms of cough; Section 2: Cough in the Clinic; 4 Clinical assessment of cough; 5 Measurement and assessment of cough; 6 Cough sensitivity: the use of provocation tests; 7 Causes, assessment and measurement of cough in children; 8 The quality of life in coughers; Section 3: Clinical Conditions with Cough; 9 Cough in lower airway infections; 10 Cough and gastro-oesophageal reflux
11 Cough in postnasal drip, rhinitis and rhinosinusitis12 Cough and airway hyperresponsiveness; 13 Cough in chronic obstructive pulmonary disease; 14 Cough in suppurative airway diseases; 15 Cough in cancer patients; Section 4: Pathophysiology; 16 Sensory pathways for the cough reflex; 17 Neurogenesis of cough; 18 Plasticity of vagal afferent fibres mediating cough; 19 Motor mechanisms and the mechanics of cough; 20 Mucus hypersecretion and mucus clearance in cough; 21 Animal models of cough; Section 5: Therapy 22 Mechanisms of actions of centrally acting antitussives-electrophysiological and neurochemical analysis23 Pharmacology of peripherally acting antitussives; 24 Current and potential future antitussive therapies; 25 Placebo effects of antitussive treatments on cough associated with acute upper respiratory tract infection; 26 Mucoactive agents for the treatment of cough; 27 Management of cough; Index |
| Record Nr. | UNISA-996214603403316 |
| Malden, Mass., : Blackwell Pub., 2003 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. di Salerno | ||
| ||
Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung
| Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
616.2
616.200461 |
| Altri autori (Persone) |
AdcockIan (Ian M.)
ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory organs - Diseases - Chemotherapy
Steroid drugs Drug resistance |
| ISBN |
1-281-84122-6
9786611841225 0-470-98573-9 0-470-98572-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Overcoming Steroid Insensitivity in Respiratory Disease; Contents; List of Contributors; Preface; 1 Molecular Mechanisms of Glucocorticoid Receptor Action; 1.1 Introduction; 1.2 Glucocorticoid Receptor; 1.3 Gene Induction by GR; 1.4 GR Transactivation and Histone Acetylation; 1.5 Post-translational Modifications of GR; 1.6 Repression of NF-κB-induced Inflammatory GeneExpression by GR-NF-κB; 1.7 GR-NF-κB Cross-talk; 1.8 Role of HDAC2 in Glucocorticoid Function; 1.9 Overexpression of HDAC2 Restores Glucocorticoid Sensitivity in Alveolar Macrophages
1.10 Acetylation of hsp90 and Regulation of GR Function 1.11 Other Mechanisms of GR Action; 1.12 Conclusions; 2 Side Effects of Topical and Oral Glucocorticoids; 2.1 Introduction; 2.2 Glucocorticoid-induced Side Effects; 2.3 Summary; 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity; 3.1 Introduction; 3.2 Overview of Classic GR Function; 3.3 GR Subtypes Arising from Alternative Splicing; 3.4 GR Subtypes arising from Alternative Translation Initiation; 3.5 Conclusions; 4 Dissociated Glucocorticoids; 4.1 Introduction 4.2 Asthma and Chronic Obstructive Pulmonary Disease are Chronic Inflammatory Diseases of the Airways 4.3 Regulation of Inflammatory Gene Expression; 4.4 Effects on Inflammation; 4.5 Mechanisms of Glucocorticoid Action; 4.6 Dissociated Glucocorticoids; 4.7 GR Cross-talk with Other Nuclear Receptors and Coactivators; 4.8 Overcoming Steroid Insensitivity; 4.9 Glucorticoid-sparing Approaches to Anti-inflammatory Therapy; 4.10 Conclusion; 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms; 5.1 Introduction; 5.2 Molecular Mechanisms of Glucocorticoid Resistance 5.3 Conclusions 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects; 6.1 Introduction; 6.2 Effects of Corticosteroids in Asthma; 6.3 Definition of Corticosteroid Insensitivity; 6.4 Oral CS Responsiveness in Asthma; 6.5 ICS Responsiveness in Asthma; 6.6 CS Responsiveness in Severe Asthma; 6.7 Surrogates for CS Responsiveness in Asthma; 6.8 Pharmacokinetics of Systemic CS in Severe Asthma; 6.9 CS Responsiveness in Cigarette Smokers and Chronic Obstructive Pulmonary Disease; 6.10 Other Diseases of CS Insensitivity; 6.11 Conclusions 7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms 7.1 Introduction; 7.2 GR Abnormalities; 7.3 GR Nuclear Translocation; 7.4 Cross-talk with Transcription Factors; 7.5 NF-κB, GR, Histones and Chromatin Remodelling; 7.6 Epigenetics and Asthma; 7.7 Conclusions; 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness; 8.1 Oxidative Stress; 8.2 Cigarette Smoke/Oxidative Stress-InducedNF-κB-mediated Pro-inflammatory Gene Expression; 8.3 Histone Acetylation and Deacetylation; 8.4 Corticosteroids; 8.5 Histone Deacetylases; 8.6 Reversing Glucocorticoids / Corticosteroid Resistance 8.7 Conclusion |
| Record Nr. | UNINA-9910144107803321 |
| Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||
Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung
| Overcoming steroid insensitivity in respiratory disease [[electronic resource] /] / edited by Ian M. Adcock and Kian Fan Chung |
| Edizione | [1st ed.] |
| Pubbl/distr/stampa | Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 |
| Descrizione fisica | 1 online resource (310 p.) |
| Disciplina |
616.2
616.200461 |
| Altri autori (Persone) |
AdcockIan (Ian M.)
ChungK. Fan <1951-> |
| Soggetto topico |
Respiratory organs - Diseases - Chemotherapy
Steroid drugs Drug resistance |
| ISBN |
1-281-84122-6
9786611841225 0-470-98573-9 0-470-98572-0 |
| Formato | Materiale a stampa |
| Livello bibliografico | Monografia |
| Lingua di pubblicazione | eng |
| Nota di contenuto |
Overcoming Steroid Insensitivity in Respiratory Disease; Contents; List of Contributors; Preface; 1 Molecular Mechanisms of Glucocorticoid Receptor Action; 1.1 Introduction; 1.2 Glucocorticoid Receptor; 1.3 Gene Induction by GR; 1.4 GR Transactivation and Histone Acetylation; 1.5 Post-translational Modifications of GR; 1.6 Repression of NF-κB-induced Inflammatory GeneExpression by GR-NF-κB; 1.7 GR-NF-κB Cross-talk; 1.8 Role of HDAC2 in Glucocorticoid Function; 1.9 Overexpression of HDAC2 Restores Glucocorticoid Sensitivity in Alveolar Macrophages
1.10 Acetylation of hsp90 and Regulation of GR Function 1.11 Other Mechanisms of GR Action; 1.12 Conclusions; 2 Side Effects of Topical and Oral Glucocorticoids; 2.1 Introduction; 2.2 Glucocorticoid-induced Side Effects; 2.3 Summary; 3 Glucocorticoid Receptor Subtypes and Steroid Sensitivity; 3.1 Introduction; 3.2 Overview of Classic GR Function; 3.3 GR Subtypes Arising from Alternative Splicing; 3.4 GR Subtypes arising from Alternative Translation Initiation; 3.5 Conclusions; 4 Dissociated Glucocorticoids; 4.1 Introduction 4.2 Asthma and Chronic Obstructive Pulmonary Disease are Chronic Inflammatory Diseases of the Airways 4.3 Regulation of Inflammatory Gene Expression; 4.4 Effects on Inflammation; 4.5 Mechanisms of Glucocorticoid Action; 4.6 Dissociated Glucocorticoids; 4.7 GR Cross-talk with Other Nuclear Receptors and Coactivators; 4.8 Overcoming Steroid Insensitivity; 4.9 Glucorticoid-sparing Approaches to Anti-inflammatory Therapy; 4.10 Conclusion; 5 Generalized Glucocorticoid Insensitivity: Clinical Phenotype and Molecular Mechanisms; 5.1 Introduction; 5.2 Molecular Mechanisms of Glucocorticoid Resistance 5.3 Conclusions 6 Corticosteroid Responsiveness in Asthma: Clinical Aspects; 6.1 Introduction; 6.2 Effects of Corticosteroids in Asthma; 6.3 Definition of Corticosteroid Insensitivity; 6.4 Oral CS Responsiveness in Asthma; 6.5 ICS Responsiveness in Asthma; 6.6 CS Responsiveness in Severe Asthma; 6.7 Surrogates for CS Responsiveness in Asthma; 6.8 Pharmacokinetics of Systemic CS in Severe Asthma; 6.9 CS Responsiveness in Cigarette Smokers and Chronic Obstructive Pulmonary Disease; 6.10 Other Diseases of CS Insensitivity; 6.11 Conclusions 7 Glucocorticoid-insensitive Asthma: Molecular Mechanisms 7.1 Introduction; 7.2 GR Abnormalities; 7.3 GR Nuclear Translocation; 7.4 Cross-talk with Transcription Factors; 7.5 NF-κB, GR, Histones and Chromatin Remodelling; 7.6 Epigenetics and Asthma; 7.7 Conclusions; 8 Cigarette Smoke, Oxidative Stress and Corticosteroid Responsiveness; 8.1 Oxidative Stress; 8.2 Cigarette Smoke/Oxidative Stress-InducedNF-κB-mediated Pro-inflammatory Gene Expression; 8.3 Histone Acetylation and Deacetylation; 8.4 Corticosteroids; 8.5 Histone Deacetylases; 8.6 Reversing Glucocorticoids / Corticosteroid Resistance 8.7 Conclusion |
| Record Nr. | UNINA-9910812495003321 |
| Chichester, England ; ; Hoboken, NJ, : J. Wiley, c2008 | ||
| Materiale a stampa | ||
| Lo trovi qui: Univ. Federico II | ||
| ||